Stem cell maintenance: aMPLe splicing choices

Stem cell maintenance: aMPLe splicing choices.

OTT was first identified as part of the recurrent t(1;22) translocation in acute megakaryoblastic leukemia (AMKL) and was called OTT for “one twenty-two.” OTT1 is also known as RNA binding motif protein 15 (RBM15). Like other RNA binding motif proteins, RBM15 contains RNA recognition motifs (RRMs), 3 in total, which can bind to RNA and, at least for some RRMs, may also bind to DNA. Lifelong mai...

HSC niche: ample room for every guest stem cell.

Alternative splicing modulates stem cell differentiation.

Stem cells have the surprising potential to develop into many different cell types. Therefore, major research efforts have focused on transplantation of stem cells and/or derived progenitors for restoring depleted diseased cells in degenerative disorders. Understanding the molecular controls, including alternative splicing, that arise during lineage differentiation of stem cells is crucial for ...

Stem cell maintenance in a different niche

To overcome the difficulty of controlling stem cell fate and function in applications to regenerative medicine, a number of alternative approaches have been made. Recent reports demonstrate that a non-cellular niche modulating the biophysical microenvironment with chemical factors can support stem cell self-renewal. In our previous studies, early establishment was executed to optimize biophysic...

Maintenance of stem cell populations in plants.

Flowering plants have the unique ability to produce new organs continuously, for hundreds of years in some species, from stem cell populations maintained at their actively growing tips. The shoot tip is called the shoot apical meristem, and it acts as a self-renewing source of undifferentiated, pluripotent stem cells whose descendents become incorporated into organ and tissue primordia and acqu...